Obama administration it’s stated policy has been seeking to change nuclear calculations of Iran’s Leaders, and to achieve this goal has used sanctions to paralyze Iranian Economy. The main question of article is “what is the main expect of U.S.A. from function of sanction regimes against Iran? And by which mechanism is going to change Iran’s calculation?” Author argues that making political divide among Political Elites of system and Uprising are the most important goals of U.S.A. from imposing sanction regimes against Iran.